Shamima Begum, 15, Kadiza Sultana, 16 and their unnamed 15-year-old friend flew from Gatwick to Turkey on Tuesday.
Police have issued an urgent appeal for help in finding them, suggesting they are "extremely vulnerable".
The trio are friends with a fourth girl who travelled to Syria in December.
Abdul Samid, a parent governor at Bethnal Green Academy, which all
four girls attended, said there was "absolutely not" any radicalisation
at the school.
"I'm 100% confident - with the head and the senior leadership
team and the whole school - that we've done everything to put in
measures that safeguard all the children that attend the school," he
said.
He said he did not believe the girls were trying to get to Syria.
"I still don't believe that they are going anywhere other
than a holiday - because this is how they were dressed and this is how
they looked and this is how they packed," he added.
'Grave danger'
However, Metropolitan Police Commander Richard Walton said he
believed the girls intended to travel to Syria, where they would be "in
grave danger".
He said he hoped they would "hear our concerns for their
safety and have the courage to return now, back to their families who
are so worried about them."
Police hope the girls may still be in Turkey, as severe winter weather is currently affecting transport links in the country.
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